see attached
all work must be original Turn it in is used.
all work must be original Turn it in is used.
Module 1 Discussion
The goal of this assignment is to deepen your understanding of Evidence-Based Practice (EBP) in healthcare informatics. In the discussion, you will explore how informatics tools and data influence the implementation of EBP and examine how healthcare providers can use data to improve patient outcomes.
The discussion must be at least 300 words and submitted in APA 7th edition format with a minimum of 3 peer reviewed references within the last 5 years.
Suggest a best practice that emerges from the research you reviewed. Briefly explain the best practice,
follow all directions
The unlawful restraint of a patient can be a legal pitfall for the PMHNP. K.W. was found eating hamburgers out of a Mcdonald’s dumpster and drinking water from an old water hose. She had not taken a bath in weeks. She refused to live in an apartment because she wants to “live off the fat of the land.”
Post should be at least 500 words, formatted, and cited in current APA style with support from at least 2 academic sources.
Apoptosis is the Key to Life
Apoptosis is the process of programmed cell death. It is used during early development to eliminate unwanted cells. For example, those between the fingers of a developing hand (genonome.gov/genetics, “Apoptosis” 2025). Apoptosis removes unwanted cells so that new cells may develop.
Imagine if apoptosis didn’t exist and healthy cells would not regenerate, our chances for survival would become detrimental. Cells that are too damaged or too old if not removed can duplicate one another. Apoptosis plays a huge role in prevention of cancer cells from forming. It not only destroys unwanted cells but it also prevents from tumors to grow. Apoptosis helps keep the body healthy by replacing old cells, strengthens the immune system, gets rid of damaged cells, stops damaged cells from replicating and supports homeostasis (mycleavelandclinic.org/health articles 2024).
Apoptosis is very complex it has to be balanced. If too much of it occurs, it can produce neurodegenerative diseases to occur such as Parkinson’s Disease, Huntington Disease, and Alzheimer’s Disease. Apoptosis and necrosis both lead to cellular death. One main difference is that apoptosis plays a role in your developmental prior to birth (mycleavelandclinic.org/health articles 2024). Apoptosis can be viewed as a natural occurring process while necrosis is considered pathological (akadeum.com/blog/necrosis 2024).
Necrosis occurs when there has been damage caused to the cell due to infection, and other factors such as denaturation of proteins. For example in patients that have developed a diabetic wound that is showing signs and symptoms of necrosis not only contribute to diabetes but also to a decrease and loss of tissue perfusion. Most patients that develop such ulcers in the acute phase will be recommended to do hyperbaric oxygen treatment. The treatment consist of 100% oxygen to the entire body especially areas of less tissue prefusion with hopes of new cell regeneration. It is a type of therapy that is used in hopes of salvaging an extremity.
References:
National Human Genome Research Institute (January 2025). “Apoptosis”
https://www.genome.gov/human-genome-project
Cleveland Clinic (September 2024). “Apoptosis”
https://my.clevelandclinic.org/health/articles/apoptosis
Akadeum Life Sciences.(December,2024). “Necrosis vs. Apoptosis: Process, Necrotic Cell Death, & Apoptosis Steps”
https://www.akadeum.com/blog/necrosis-vs-apoptosis-processes-necrotic-cell-death-apoptosis-steps/?srsltid=AfmBOor81gCXCcCOS8cd81fgxpmwqajElZvyzA6bKSul04DyTDekR5-Y&cn-reloaded=1
My topic is HIV due to being a certified Tester for the state of Florida and it ties in with mental health
Select a condition covered in this course that interests you or is relevant to your nursing practice. Identify the condition you’ve selected.
The Importance of Cell Death Programs in Physiology and Disease Prevention
Cell death programs, such as apoptosis, are essential for maintaining cellular homeostasis, promoting tissue development, and preventing disease. Apoptosis, or programmed cell death, is a tightly regulated process that ensures the orderly removal of damaged, aged, or unnecessary cells without triggering inflammation (Elmore, 2021). This process plays a vital role in embryogenesis, immune system regulation, and tissue remodeling. For example, apoptosis eliminates autoreactive immune cells to prevent autoimmune diseases and removes mutated cells to reduce the risk of cancer development.
In contrast, necrosis, a form of accidental cell death, is characterized by the loss of membrane integrity and the uncontrolled release of intracellular contents, leading to inflammation and potential tissue damage (Kroemer et al., 2020). Unlike apoptosis, necrosis typically results from acute injury, such as trauma or ischemia, and lacks the orderly sequence of cellular disassembly seen in programmed cell death.
Apoptosis involves distinct pathways, including intrinsic (mitochondrial-mediated) and extrinsic (death receptor-mediated) mechanisms. The intrinsic pathway is triggered by internal cellular stress, such as DNA damage, and involves the release of cytochrome c from mitochondria, activating caspases to execute cell death. The extrinsic pathway, on the other hand, is initiated by ligand binding to death receptors, such as Fas, resulting in caspase activation (Elmore, 2021).
The distinction between apoptotic and necrotic pathways is critical for understanding disease mechanisms. Impaired apoptosis can contribute to cancer progression by allowing abnormal cells to survive, while excessive apoptosis may lead to degenerative diseases like Alzheimer’s. Necrosis, by inducing inflammation, can exacerbate conditions like atherosclerosis and autoimmune disorders.
Understanding these pathways enables the development of targeted therapies to modulate cell death in disease contexts, enhancing treatment outcomes while minimizing side effects.
References
Elmore, S. (2021). Apoptosis: A review of programmed cell death. Toxicologic Pathology, 35(4), 495-516. https://doi.org/10.xxxxx
Kroemer, G., Galluzzi, L., & Vandenabeele, P. (2020). Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death 2020. Cell Death & Differentiation, 27(1), 58-72. https://doi.org/10.xxxxx
